こちらでは研究代表者：西村智が発表した英語論文についてご紹介しています。

2012.

Inhibition of Stabilin-2 elevates circulating hyaluronic acid levels and prevents tumor metastasis
Hirose Y, Saijou E, Sugano Y, Takeshita F, Nishimura S, Nonaka H, Chen Y-R, Sekine K, Kido T, 
Nakamura T, Kato S, Kanke T, Nakamura K, Nagai R, Ochiya T, Miyajima A
PNAS 2012, in publication

In vivo imaging visualizes discoid platelet aggregations without endothelium disruption and implicates contribution 
of inflammatory cytokine and integrin signaling.
Nishimura S, Manabe I, Nagasaki M, Kakuta S, Iwakura Y, Takayama N, Ooehara J, Otsu M, Kamiya A, Petrich B, Urano T, 
Kadono T, Sato S, Aiba A, Yamashita H, Sugiura S, Kadowaki T, Nakauchi H, Eto K, Nagai R.
Blood. 2012 ;119(8):e45-56. <Manuscript Download>

2011

Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle.
Kubota T, Kubota N, Kumagai H, Yamaguchi S, Kozono H, Takahashi T, Inoue M, Itoh S, Takamoto I, Sasako T, Kumagai K,
 Kawai T, Hashimoto S, Kobayashi T, Sato M, Tokuyama K, Nishimura S, Tsunoda M, Ide T, Murakami K, Yamazaki T, Ezaki O, 
Kawamura K, Masuda H, Moroi M, Sugi K, Oike Y, Shimokawa H, Yanagihara N, Tsutsui M, Terauchi Y, Tobe K, Nagai R, 
Kamata K, Inoue K, Kodama T, Ueki K, Kadowaki T.
Cell Metab. 2011;13(3):294-307.

2010

Takayama N, Nishimura S, Nakamura S, Shimizu T, Ohnishi R, Endo H, Yamaguchi T, Otsu M, Nishimura K, Nakanishi M, Sawaguchi A, Nagai R, Takahashi K, Yamanaka S, Nakauchi H, Eto K.
Transient activation of c-MYC expression is critifal for efficient platelet generation from human induced pluripotent stem cells.  
Journal of Experimental Medicine, 2010; 207(13):2817-2830 <Manuscript Download> <Editorial Manuscript Download> 

Norifumi T, Manabe I, Uchino Y, Eguchi K, Matsumoto S, Nishimura S, Shindo T, Sano M, Otsu K, Snider P, Conway S, Nagai R 
Cardiac fibroblasts are essential for the adaptive response of the murine heart to pressure overload 
J Clin Invest., 2010, 120(1): 254-265.

Seo K, Inagaki M, Nishimura S, Hidaka I, Sugimachi M, Hisada T, Sugiura S 
Structural Heterogeneity in the Ventricular Wall Plays a Significant Role in the Initiation of Stretch-Induced Arrhythmias in Perfused Rabbit Right Ventricular Tissues and Whole Heart Preparations 
Circ Res, 2010, 106,176-184.

2009

Nishimura S, Manabe I, Nagasaki M, Eto K, Yamashita H, Ohsugi M, Otsu M, Hara K, Ueki K, 
Sugiura S, Yoshimura K, Kadowaki T, Nagai R.
CD8⁺ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity
Nature Medicine, 2009, 15:8, 914-920. <Manuscript Download>

Nishimura S, Manabe I, Nagai R.
Adipose Tissue Inflammation in Obesity and Metabolic Syndrome
Discovery Medicine 2009, vol 8, no 41, 55-60.

Yagi N, Manabe I, Tottori T, Ishihara A, Ogata F, Kim JH, Nishimura S, Fujiu K, Oishi Y, Itaka K, Kato Y, Yamauchi M, Nagai R.
A nanoparticle system specifically designed to deliver short interfering RNA inhibits tumor growth in vivo.
Cancer Res. 2009 15;69(16):6531-8.

Suga H, Eto H, Shigeura T, Inoue K, Aoi N, Kato H, Nishimura S, Manabe I, Gonda K, Yoshimura K.
IFATS Series: FGF-2-induced HGF Secretion By Adipose-Derived Stromal Cells Inhibits Post-Injury Fibrogenesis 
Through A JNK-Dependent Mechanism.
Stem Cells, 2009;28:238-249.

Nishimura S, Nagasaki M, Manabe I, Kadowaki T, Nagai R. 
Obese adipose tissue remodeling, malfunctioning, and chronic inflammation visualized by in vivo molecular imaging 
Inflammation and Regeneration,2009,29(2),126-130.

2008

Nishimura S
In vivo molecular imaging revealed chronic inflammation and vascular malfunction in obese adipose tissue in metabolic syndrome (abstract) 
Experimental & Clinical Cardiology, 2008;13(2):104

Nishimura S, Seo K, Nagasaki M, Hosoya Y, Yamashita H, Fujita H, Nagai R, Sugiura S. 
Responses of single ventricular myocytes to dynamic axial stretching. 
Progress in Biophysics and Molecular Biology, 2008;97:282-297.

Ohnuki Y, Nishimura S, Sugiura S, Saeki Y. 
Phosphorylation Status of Regulatory Proteins and Functional Characteristics in Myocardium of Dilated Cardiomyopathy of Syrian Hamsters. 
J Physiol Sci, 2008;58(1):15-20

Nishimura S,　Manabe I, Nagasaki M, Seo K, Yamashita H, Hosoya Y, Ohsugi M, Tobe K, Kadowai T, Nagai R, Sugiura S. 
In vivo imaging in mice reveals local cell dynamics and inflammation in obese adipose tissue 
J Clin Invest. 2008, 118(2): 710-721. <Manuscript Download>

2007

Nishimura S, Manabe I, Nagasaki M, Hosoya Y, Yamashita H, Fujita H, Ohsugi M, Tobe K, Kadowaki T, Nagai R, Sugiura S. 
Adipogenesis in obesity requires close interplay between differentiating adipocytes, stromal cells and blood vessels 
Diabetes. 2007,56:1517-1526. <Manuscript Download>

Nishimura S, Manabe I, Nagasaki M, Hosoya Y, Kadowaki T, Nagai R, Sugiura S 
Adipose Tissue Remodeling and Malfunctioning in Obesity Revealed by in vivo Molecular Imaging 
Bioimages 2007,15:9-15.

2006 

Nishimura S, Kawai Y, Nakajima T, Hosoya Y, Fujita H, Katoh M, Yamashita H, Nagai R, and Sugiura S. 
Membrane potential of rat ventricular myocytes responds to axial stretch in phase, amplitude and speed‐dependent manners. 
Cardiovascular Research, 2006;72(3):403-11.

Sugiura S, Nishimura S, Yasuda SI, Hosoya Y, Katoh K. 
Carbon fiber technique for the investigation of single cell mechanics in intact cardiac myocytes. 
Nature Protocols, 2006; 1(3): 1453-1457.

Kamei N, Tobe K, Suzuki R, Ohsugi M, Watanabe T, Kubota N, Ohtsuka-Kowatari N, Kumagai K, Sakamoto K, Kobayashi M, Yamauchi T, Ueki K, Oishi Y, Nishimura S, Manabe I, Hashimoto H, Ohnishi Y, Ogata H, Tokuyama K, Tsunoda M, Ide T, Murakami K, Nagai R, Kadowaki T. Overexpression of MCP-1 in adipose tissues causes macrophage recruitment and insulin resistance. 
J Biol Chem. 2006; 281(36):26602-14

Nishimura S, Nagai S, Katoh M, Yamashita H, Saeki Y, Okada J, Hisada T, Nagai R,Sugiura S. 
Microtubules modulate the stiffness of cardiomyocytes against shear stress. 
Circulation Research. 2006;98(1):81-7.

Nishimura S, Nagai S, Sata M, Katoh M, Yamashita H, Saeki Y, Nagai R, Sugiura S. 
Expression of Green Fluorescent Protein Impairs the Force-Generating Ability of Isolated Rat Ventricular Cardiomyocytes. 
Mol Cell Biochem. 2006;286(1-2):59-65..

2005 

Nishimura S, Yamashita H, Katoh M, Yamada KP, Sunagawa K, Saeki Y, Ohnuki Y, Nagai R, Sugiura S. 
Contractile dysfunction of cardiomyopathic hamster myocytes is pronounced under high load conditions.　
J Mol Cell Cardiol. 2005;39(2):231-9.

Nagasaki M, Nishimura S, Ohtaki E, Kasegawa H, Matsumura T, Nagayama M, Koyanagi T, Tohbaru T, Misu K, Asano R, Sumiyoshi T, Hosoda S. 
The echocardiographic determinants of functional mitral regurgitation differ in ischemic and non-ischemic cardiomyopathy.　 
Int J Cardiol. 2005;108(2):171-176.

Okada J, Sugiura S, Nishimura S, Hisada T. 
Three-dimensional simulation of calcium waves and contraction in cardiomyocytes using the finite element method. 
Am J Physiol Cell Physiol. 2005;288(3):C510-22.

2004 

Nishimura S, Yasuda S, Katoh M, Yamada KP, Yamashita H, Saeki Y, Sunagawa K, Nagai R, Hisada T, Sugiura S. 
Single cell mechanics of rat cardiomyocytes under isometric, unloaded, and physiologically loaded conditions. 
Am J Physiol Heart Circ Physiol. 2004 Jul;287(1):H196-202.

Saeki Y, Kobayashi T, Yasuda S, Nishimura S, Sugiura S, Yamashita H, Sugi H.
Role of Ca2+ in determining the rate of tension development and relaxation in rat skinned myocardium. 
J Mol Cell Cardiol. 2004 Mar;36(3):371-80. 

2003 

Yasuda S, Sugiura S, Yamashita H, Nishimura S, Saeki Y, Momomura S, Katoh K, Nagai R, Sugi H.
Unloaded shortening increases peak of Ca2+ transients but accelerates their decay in rat single cardiac myocytes. 
Am J Physiol Heart Circ Physiol. 2003 Aug;285(2):H470-5. 

Ryu T, Nishimura S, Miura H, Yamada H, Morita H, Miyazaki H, Kitamura S, Miura Y, Saito T.
Thrombopoietin-producing hepatocellular carcinoma. 
Intern Med. 2003 Aug;42(8):730-4. 

2002 

Nishimura S, Toubaru T, Ootaki E, Sumiyoshi T.
Follow-up study of aortic-valve replacement surgery in patients with Takayasu's disease complicated by aortic regurgitation. 
Circulation Journal. 2002 Jun;66(6):564-6. 

Nishimura S, Miura H, Yamada H, Shinoda T, Kitamura S, Miura Y.
Acute onset of nephrotic syndrome during interferon-alpha retreatment for chronic active hepatitis C.　
J Gastroenterol. 2002;37(10):854-8. 

Nishimura S, Shinoda T, Suzuki Y, Yoshimoto H, Yamada H, Miura H, Kitamura S, Arimura Y
Drug-induced MPO-ANCA-positive necrotizing crescentic glomerulonephritis preceded by granulomatous hepatitis 
Clin and Exp Nephrol. 2002;6(2):118-20. 

2001 

Nishimura S, Miura H, Yamada H, Ryu T, Miura Y.
Rapidly progressive tabes dorsalis associated with selective IgA deficiency. 
Intern Med. 2001 Sep;40(9):972-5.